Design refinement from beginning of processing to end

The Progenokine Process takes in all aspects of regeneration with a unique design to utilize not just cells, but their signaling molecules (growth factors and cytokines.)

Our processing techniques go above and beyond the industry standard to ensure verifiable conformance, efficiency for practitioners and safety for patients. The Progenokine Process is the premier alternative to current industry cryopreservation media. 

NOT JUST CELLS – Cells need signaling molecules 

Cells need their signaling molecules to recruit recipient cells and modulate the micro-environment. The Progenokine Process was designed with this in mind: to utilize the cells and signaling molecules (growth factors and cytokines) to produce a product with the highest impact possible.

Burst Biologics and the Progenokine Process ensure a consistent, reliable product.

Upholding the highest standards in tissue processing

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Only highest grade plastics used during manufacturing

Sterile High Density Plastics

USP CLASS VI

Certified SAL-6

Certified DNase free

Certified RNase free

Certified Non-Pyrogenic free

Meets or exceeds (USP Guidelines)

Only USP grade reagents

The United States Pharmacopeial Convention, Incorporated, (USP) is a scientific nonprofit organization that sets standards for the identity, strength, quality, and purity of medicines, food ingredients, and dietary supplements manufactured, distributed and consumed worldwide.

Burst Biologics only uses non-enzymatic reagents that are of chemical grade of sufficient purity to meet or exceed requirements of the U.S. Pharmacopeia (USP); acceptable for food, drug, or medicinal use.

Donor testing above and beyond FDA requirements

Cytomegalovirus IgG antibody

Cytomegalovirus IgM antibody

West Nile Virus Nucleic Acid Test

Zika Virus PCR test

Zika Virus IgM antibody

Hepatitis C Nucleic Acid Test

Human T-lymphotropic virus I antibody

Human T-lymphotropic virus II antibody

Human Immunodeficiency virus Type I & Type II plus O antibodies

Rapid Plasma Reagin (RPR) (Syphilis) (Nontreponemal)

CAPTIA (Syphilis) (Treponemal)

Hepatitis B Antibody

Hepatitis B Antigen

Hepatitis B Nucleic Acid Test

Hepatitis C Antibody

Every lot strictly tested according to release criteria

Donor Medical History

Donor Risk Assessment

Donor Physical Exam

Incoming Bioburden

Final Product Testing

Cell Content

Tissue Transit Time

Sterility (USP Guidelines)

Designed with end-user in mind

Using a “Thaw and Go” approach, the Progenokine Process is designed to eliminate the need for pre-application processing. The selective composition of our process offers superior protection from stressors of the freeze/thaw cycle.

Our processing techniques DO NOT include using harmful cryopreservative media (such as DMSO).  Most other industry manufacturers either include DMSO in their media, or do not promote the need for pre-washing. DMSO is a potentially harmful substance that can adversely interact with internal cellular pathways.

With no DMSO or need for pre-application processing, there can be more time directed towards what matters most — patient care.

Ordering products that utilize The Progenokine Process has never been easier with My BioPortal. 

DMSO-free processing

The Progenokine Process utilizes non-toxic, DMSO-free cryopreservation media while still maintaining a high level of cell integrity and viability.

Why say no to DMSO?

DMSO is a penetrative substance that may adversely interact with the cells at room temperature. With the potential to penetrate the membrane, DMSO can also adversely interact with internal cellular pathways –  causing them to not function properly.

Most HCT/Ps that are frozen and contain DMSO require washing before they are applied to the patient. This additional process takes valuable time away from the physicians, their staff, and their patients.

The patent pending Progenokine processing technique incorporates unique breakthroughs in cryoprotection exclusive to Burst Biologics.